Buckingham Margaret, Meilhac Sigolène, Zaffran Stéphane
Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, 25 Rue du Dr Roux, 75015 Paris, France.
Nat Rev Genet. 2005 Nov;6(11):826-35. doi: 10.1038/nrg1710.
Cardiogenesis is an exquisitely sensitive process. Any perturbation in the cells that contribute to the building of the heart leads to cardiac malformations, which frequently result in the death of the embryo. Previously, the myocardium was thought to be derived from a single source of cells. However, the recent identification of a second source of myocardial cells that make an important contribution to the cardiac chambers has modified the classical view of heart formation. It also has an important influence on the interpretation of mutant phenotypes in the mouse, with consequences for the classification and prognosis of human congenital heart defects.
心脏发生是一个极其敏感的过程。任何参与心脏构建的细胞发生扰动都会导致心脏畸形，这常常导致胚胎死亡。以前，心肌被认为来源于单一的细胞来源。然而，最近发现的另一种对心腔有重要贡献的心肌细胞来源改变了心脏形成的经典观点。它对小鼠突变体表型的解释也有重要影响，对人类先天性心脏缺陷的分类和预后产生影响。
