Srivastava Deepak
Gladstone Institute of Cardiovascular Disease and Department of Pediatrics and Biochemistry, University of California, San Francisco, CA 94158, USA.
Cell. 2006 Sep 22;126(6):1037-48. doi: 10.1016/j.cell.2006.09.003.
The cues governing cardiac cell-fate decisions, cardiac differentiation, and three-dimensional morphogenesis are rapidly being elucidated. Several themes are emerging that are relevant for childhood and adult heart disease and the growing field of stem cell biology. This review will consider our current understanding of cardiac cell-fate determination and cardiogenesis--largely derived from developmental studies in model organisms and human genetic approaches--and examine future implications for diagnosis, prevention, and treatment of heart disease in the young and old.
调控心脏细胞命运决定、心脏分化和三维形态发生的线索正在迅速被阐明。一些与儿童和成人心脏病以及不断发展的干细胞生物学领域相关的主题正在浮现。本综述将探讨我们目前对心脏细胞命运决定和心脏发生的理解——主要来自模式生物的发育研究和人类遗传学方法——并研究其对年轻人和老年人心脏病诊断、预防和治疗的未来影响。
