Longo Valter D, Mitteldorf Joshua, Skulachev Vladimir P
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089, USA.
Nat Rev Genet. 2005 Nov;6(11):866-72. doi: 10.1038/nrg1706.
Ageing is widely believed to be a non-adaptive process that results from a decline in the force of natural selection. However, recent studies in Saccharomyces cerevisiae are consistent with the existence of a programme of altruistic ageing and death. We suggest that the similarities between the molecular pathways that regulate ageing in yeast, worms, flies and mice, together with evidence that is consistent with programmed death in salmon and other organisms, raise the possibility that programmed ageing or death can also occur in higher eukaryotes.
人们普遍认为衰老是非适应性过程，是自然选择压力下降的结果。然而，最近对酿酒酵母的研究与利他性衰老和死亡程序的存在相一致。我们认为，调节酵母、蠕虫、果蝇和小鼠衰老的分子途径之间的相似性，以及与鲑鱼和其他生物中程序性死亡相一致的证据，增加了程序性衰老或死亡也可能在高等真核生物中发生的可能性。
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