肌动蛋白细胞骨架：细胞凋亡和衰老的关键调节因子？
The actin cytoskeleton: a key regulator of apoptosis and ageing?
作者信息
Gourlay Campbell W, Ayscough Kathryn R
机构信息
Department of Molecular Biology and Biotechnology, Firth Court, Western Bank, University of Sheffield, Sheffield, S10 2TN, UK.
出版信息
Nat Rev Mol Cell Biol. 2005 Jul;6(7):583-9. doi: 10.1038/nrm1682.
DOI:10.1038/nrm1682
PMID:16072039
Abstract
Evidence from many organisms has shown that the accumulation of reactive oxygen species (ROS) has a detrimental effect on cell well-being. High levels of ROS have been linked to programmed cell death pathways and to ageing. Recent reports have implicated changes to the dynamics of the actin cytoskeleton in the release of ROS from mitochondria and subsequent cell death.
摘要
来自许多生物体的证据表明，活性氧（ROS）的积累对细胞健康有不利影响。高水平的ROS与程序性细胞死亡途径和衰老有关。最近的报道表明，肌动蛋白细胞骨架动力学的变化与线粒体释放ROS及随后的细胞死亡有关。
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