蛋白质组学在糖尿病中的应用。

The application of proteomics to diabetes.

作者信息

Scott Eleanor M, Carter Angela M, Findlay John B C

机构信息

Academic Unit of Molecular Vascular Medicine, The LIGHT Laboratories, Clarendon Way, University of Leeds, Leeds LS2 9JT, UK.

出版信息

Diab Vasc Dis Res. 2005 May;2(2):54-60. doi: 10.3132/dvdr.2005.009.

DOI:10.3132/dvdr.2005.009

PMID:16305059

Abstract

Poteomics is the investigation of all the proteins and their various modifications making up a system, be that a cell, tissue or organism. The techniques involved in proteomics allow the global screening of complex samples of proteins and provide qualitative and quantitative evidence of altered protein expression. This lends itself to the investigation of the molecular mechanisms underpinning disease processes and the effects of treatment. This review describes the main techniques of proteomics and how they have begun to be applied to diabetes research.

摘要

蛋白质组学是对构成一个系统（无论是细胞、组织还是生物体）的所有蛋白质及其各种修饰进行的研究。蛋白质组学所涉及的技术能够对复杂的蛋白质样本进行全面筛查，并提供蛋白质表达改变的定性和定量证据。这有助于对疾病过程的分子机制以及治疗效果进行研究。本综述描述了蛋白质组学的主要技术以及它们如何开始应用于糖尿病研究。