Gender specific association of CYP2C9*3 with hyperlipidaemia in Chinese.
作者信息
Luo Chen-Hui, Wang An, Zhu Rong-Hua, Zhang Wei-Xia, Mo Wei, Yu Bang-Ning, Chen Guo-Lin, Ou-Yang Dong-Sheng, Duan Xiao-Hong, Abd El-Aty A M, Zhou Hong-Hao
机构信息
Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, Hunan 410078, China.
出版信息
Br J Clin Pharmacol. 2005 Dec;60(6):629-31. doi: 10.1111/j.1365-2125.2005.02498.x.
AIMS
To investigate the association of CYP2C9*3 and *6 with hyperlipidaemia in Chinese.
METHODS
Four hundred and seventy-six Chinese participated in the study, including 211 uncomplicated hyperlipidaemic patients and 265 healthy controls. PCR-RFLP was used to identify CYP2C9*3 and *6.
RESULTS
CYP2C96 was not detected in this study. The allelic frequency of CYP2C93 was 0.039 (95% CI 0.022, 0.056). A nonsignificant difference existed in CYP2C93 frequencies between males and females (P = 0.605, OR = 1.194, 95% CI 0.610, 2.336), patients and controls (P = 0.063, OR = 0.506, 95% CI 0.244, 1.049) in the total population. However, in the female group, CYP2C93 frequency in patients with hyperlipidaemia was significantly lower than that in controls (P < 0.0001, OR = 0.062, 95% CI 0.008, 0.476).
CONCLUSIONS
The association of CYP2C9*3 with hyperlipidaemia was specific for females in this Chinese population.
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