Yang Jue Quin, Morin Sandrine, Verstuyft Céline, Fan Li An, Zhang Yong, Xu Chun Di, Barbu Véronique, Funck-Brentano C, Jaillon Patrice, Becquemont Laurent
Pharmacology Department, Saint Antoine University Hospital - University Pierre et Marie Curie - Assistance Publique-Hôpitaux de Paris, Paris, France.
Fundam Clin Pharmacol. 2003 Jun;17(3):373-6. doi: 10.1046/j.1472-8206.2003.00148.x.
Cytochrome P450 2C9 (CYP2C9) is a polymorphic enzyme responsible for the metabolism of different drugs with low therapeutic index such as oral anticoagulants. CYP2C92 and CYP2C93 are two single nucleotide polymorphic allelic variants. The frequency of these alleles in different ethnic populations is extremely variable. In this study, we compared the frequencies of CYP2C9 allelic variants among 394 Chinese living in Shanghai to 151 French Caucasians living in Paris. The allelic frequencies of CYP2C9 variants of the Chinese and the French subjects were 0.963, 0.001, 0.036 and 0.77, 0.15, 0.08 for CYP2C91, CYP2C92, CYP2C93, respectively. Chinese CYP2C93 allelic frequency was twice as lower as the French subjects, but three times higher than Korean (0.036 vs. 0.011). The CYP2C92 allele could be detected in only one Chinese subject, whereas it represented the major allelic variant in French Caucasians. The low frequency of the CYP2C92 and CYP2C9*3 allelic variants in Chinese subjects does not justify their detection in clinical practice, unlike French Caucasians.
细胞色素P450 2C9（CYP2C9）是一种多态性酶，负责代谢不同的治疗指数较低的药物，如口服抗凝剂。CYP2C92和CYP2C93是两个单核苷酸多态性等位基因变体。这些等位基因在不同种族人群中的频率差异极大。在本研究中，我们比较了394名居住在上海的中国人与151名居住在巴黎的法国白种人中CYP2C9等位基因变体的频率。中国和法国受试者中CYP2C9变体的等位基因频率分别为：CYP2C91为0.963、CYP2C92为0.001、CYP2C93为0.036；以及CYP2C91为0.77、CYP2C92为0.15、CYP2C93为0.08。中国人群中CYP2C93等位基因频率比法国受试者低两倍，但比韩国人高3倍（0.036对0.011）。CYP2C92等位基因仅在一名中国受试者中检测到，而在法国白种人中它是主要的等位基因变体。与法国白种人不同，中国受试者中CYP2C92和CYP2C93等位基因变体的低频率使其在临床实践中不值得检测。
