Lubow R E, Braunstein-Bercovitz Hedva, Blumenthal Orit, Kaplan Oren, Toren Paz
Department of Psychology, Tel Aviv University, Ramat Aviv, Israel.
Child Neuropsychol. 2005 Oct;11(5):445-57. doi: 10.1080/09297040590951578.
The research was designed to determine whether the purported hemispheric asymmetries that are associated with attention deficit/hyperactivity disorder (ADHD) affect performance on a selective attention visual search task, and whether any obtained asymmetry will be modulated by methylphenidate. Two groups of children (8-15 years) with ADHD, one with methylphenidate treatment (ADHD+) and one without (ADHD+), were compared to matched controls on a two-stage visual search task. The task assessed right-left visual field asymmetries and the effects of changing a previous distractor into a target. Such a procedure, related to latent inhibition (LI; poorer performance to a previously irrelevant stimulus than to a novel one), can provide evidence for dysfunctional processing of irrelevant stimuli. All three groups exhibited the LI effect. The ADHD group, however, exhibited less LI for left- than right-side targets, an effect absent in the control and ADHD+ groups, suggesting a lateralized attentional deficit for ADHD+ that was normalized by methylphenidate.
该研究旨在确定与注意力缺陷多动障碍（ADHD）相关的所谓半球不对称性是否会影响选择性注意力视觉搜索任务的表现，以及任何获得的不对称性是否会受到哌甲酯的调节。将两组患有ADHD的儿童（8至15岁），一组接受哌甲酯治疗（ADHD+），另一组未接受治疗（ADHD-），与匹配的对照组在两阶段视觉搜索任务中进行比较。该任务评估了左右视野不对称性以及将先前的干扰物变为目标的影响。这样一个与潜伏抑制（LI；对先前无关刺激的表现比对新刺激的表现更差）相关的程序，可以为无关刺激的功能失调处理提供证据。所有三组均表现出LI效应。然而，ADHD-组对左侧目标的LI效应小于右侧目标，而对照组和ADHD+组中不存在这种效应，这表明ADHD-存在侧向注意力缺陷，而哌甲酯可使其恢复正常。
