Adams Alyce S, Zhang Fang, Mah Connie, Grant Richard W, Kleinman Ken, Meigs James B, Ross-Degnan Dennis
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave., 6th Floor, Boston, MA 02215, USA.
Diabetes Care. 2005 Dec;28(12):2844-9. doi: 10.2337/diacare.28.12.2844.
We examined race differences in diabetes outcomes over 4-8 years in a single HMO.
We identified black and white adult diabetic patients who were continuously enrolled (1992-2001) and in whom diabetes was 1) diagnosed before 1994 (n = 1,686) or 2) newly diagnosed in 1994-1997 (n = 1,280). We used hierarchical models to estimate the effect of race on average annual HbA(1c) (A1C) controlling for baseline A1C, BMI, and age, as well as annual measures of type of diabetes medications, diabetes-related hospitalization, time and the number of A1C tests, physician visits, and nondiabetes medications. Stratifying by sex accounted for significant interactions between sex and race.
At baseline, black and white patients had similar rates of A1C testing and physician visits, but blacks had higher unadjusted A1C values. In multivariate models, among patients with previously diagnosed diabetes, average A1C was nonsignificantly 0.11 higher (95% CI -0.12 to 0.34) in black than in white men but was 0.30 higher (0.14-0.46; P = 0.0007) in black than in white women. Among patients with newly diagnosed diabetes, the adjusted black-white gap was 0.49 among men (0.17-0.80; P = 0.007) and was 0.05 among women (-0.20 to -0.31), which was positive but not significant.
Factors other than the quality of care may explain persistent race differences in A1C in this setting. Future interventions should target normalization of A1C by identifying potential psychosocial barriers to therapy intensification among patients and clinicians and development of culturally appropriate interventions to aid patients in successful self-management.
我们在一家单一的健康维护组织(HMO)中研究了4至8年期间糖尿病治疗结果的种族差异。
我们确定了1992年至2001年期间持续参保的成年黑人和白人糖尿病患者,这些患者的糖尿病情况为:1)1994年之前确诊(n = 1686)或2)1994年至1997年新确诊(n = 1280)。我们使用分层模型来估计种族对平均年度糖化血红蛋白(HbA1c)(A1C)的影响,同时控制基线A1C、体重指数(BMI)和年龄,以及糖尿病药物类型、糖尿病相关住院治疗、时间和A1C检测次数、医生诊疗次数和非糖尿病药物的年度测量值。按性别分层考虑了性别与种族之间的显著交互作用。
在基线时,黑人和白人患者的A1C检测率和医生诊疗次数相似,但黑人的未调整A1C值较高。在多变量模型中,在先前确诊糖尿病的患者中,黑人男性的平均A1C比白人男性高0.11,差异无统计学意义(95%置信区间 -0.12至0.34),但黑人女性比白人女性高0.30(0.14 - 0.46;P = 0.0007)。在新确诊糖尿病的患者中,男性的调整后黑 - 白差距为0.49(0.17 - 0.80;P = 0.007),女性为0.05(-0.20至-0.31),为正值但无统计学意义。
在这种情况下,除了医疗质量之外的因素可能解释了A1C中持续存在的种族差异。未来的干预措施应通过识别患者和临床医生强化治疗的潜在社会心理障碍,并开发适合文化背景的干预措施以帮助患者成功进行自我管理,来实现A1C的正常化。