环氨基磺酸酯作为内酰胺前体。(-)-阿法诺啡的高效不对称合成。
Cyclic sulfamidates as lactam precursors. An efficient asymmetric synthesis of (-)-aphanorphine.
作者信息
Bower John F, Szeto Peter, Gallagher Timothy
机构信息
School of Chemistry, University of Bristol, UK.
出版信息
Chem Commun (Camb). 2005 Dec 14(46):5793-5. doi: 10.1039/b510761j. Epub 2005 Oct 20.
DOI:10.1039/b510761j
PMID:16307148
Abstract
A short and efficient enantioselective synthesis of (-)-aphanorphine is described based on the use of a cyclic sulfamidate to provide a suitably functionalised lactam that allows for construction of the tricyclic 3-benzazepine scaffold.
摘要
基于使用环状氨基磺酸酯来提供合适官能化的内酰胺，从而构建三环3-苯并氮杂卓骨架，描述了一种简短且高效的（-）-阿法诺啡的对映选择性合成方法。
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