Hisatome Takashi, Yasunaga Yuji, Tanaka Ryuji, Yamasaki Takuma, Ishida Osamu, Ochi Mitsuo
Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
J Orthop Sci. 2005 Nov;10(6):574-80. doi: 10.1007/s00776-005-0949-x.
The purpose of this study was to investigate the natural course of the minimally symptomatic nonoperated hip in patients with pre-osteoarthritis or early osteoarthritis in bilaterally dysplastic hips.
The material consisted of 61 patients with bilaterally dysplastic hips who underwent rotational acetabular osteotomy in their symptomatic hip and nonoperative treatment in their asymptomatic or minimally symptomatic hip. The average follow-up was 10.1 years (range 7.0-15.6 years), and the average age at the time of surgery was 38.2 years (range 20-58 years). All patients were divided into two groups by joint congruity of the nonoperated hip at surgery with rotational acetabular osteotomy.
On radiographic assessment, 1 of the 35 pre-osteoarthritis hips had developed early osteoarthritis, and 6 of the 26 early osteoarthritis hips had progressed to advanced osteoarthritis. The Kaplan-Meier survivorship analysis for the whole group of nonoperated hips, with radiographic progression of osteoarthritis as the endpoint, predicted a 10-year survival rate of 83.7% (95% confidence interval 70%-98%). Significant differences were observed in the radiographic stage (pre- and early osteoarthritis group, P=0.015) and joint congruity (good and fair group, P=0.005).
If the contralateral nonoperated hip has good joint congruity, minimal symptoms, and no or little radiographic change in patients with pre- or early osteoarthritis and bilateral acetabular dysplasia, the probability of radiographic progression is low.
本研究旨在调查双侧发育性髋关节发育不良患者中,症状轻微且未经手术治疗的髋关节在骨关节炎前期或早期骨关节炎阶段的自然病程。
研究材料包括61例双侧发育性髋关节发育不良患者,他们对有症状的髋关节进行了髋臼旋转截骨术,对无症状或症状轻微的髋关节进行了非手术治疗。平均随访时间为10.1年(范围7.0 - 15.6年),手术时的平均年龄为38.2岁(范围20 - 58岁)。所有患者根据髋臼旋转截骨术手术时未手术髋关节的关节匹配情况分为两组。
影像学评估显示,35例骨关节炎前期髋关节中有1例发展为早期骨关节炎,26例早期骨关节炎髋关节中有6例进展为晚期骨关节炎。以骨关节炎的影像学进展为终点,对整个未手术髋关节组进行Kaplan-Meier生存分析,预测10年生存率为83.7%(95%置信区间70% - 98%)。在影像学分期(骨关节炎前期和早期组,P = 0.015)和关节匹配情况(良好和一般组,P = 0.005)方面观察到显著差异。
对于骨关节炎前期或早期且双侧髋臼发育不良的患者,如果对侧未手术髋关节关节匹配良好、症状轻微且影像学改变无或极少,则影像学进展的可能性较低。