Pedersen L K, Held E, Johansen J D, Agner T
National Allergy Research Centre for Consumer Products, Gentofte Hospital, University of Copenhagen, DK-Denmark.
Br J Dermatol. 2005 Dec;153(6):1142-6. doi: 10.1111/j.1365-2133.2005.06875.x.
The benefit of alcohol-based disinfectant used on normal skin has been debated.
The objective of the present study was to compare the effects of repeated exposure to an alcohol-based disinfectant, a detergent and an alcohol-based disinfectant/detergent alternately for 10 days, including noninvasive measurements in the evaluation. Skin reactivity in irritated skin after a 4-week interval was also evaluated.
Detergent, disinfectant and alternate disinfectant and detergent were applied twice daily every 10 min for 1 h to the ventral upper arms and forearms of 17 healthy volunteers. A control area was included. After 4 weeks an SLS patch was applied to each area. Irritant reactions were quantified with a visual score recording and measurements of transepidermal water loss (TEWL) and skin colour were performed on days 1, 5, 11, 38 and 40.
On day 5 the detergent caused a higher visual score than either disinfectant applied alone or alternate disinfectant and detergent, P < 0.05. On day 11 detergent and alternate disinfectant and detergent caused a higher score than disinfectant, P < 0.05. An increased irritant response for detergent compared with disinfectant alone and alternate disinfectant and detergent was confirmed by TEWL evaluations on days 5 and 11, P < 0.001, while no significant difference was found by colour measurement. After 4 weeks, when evaluated by colour measurement, significantly less response to the SLS patch was found on the disinfectant-treated area compared with the control area and detergent area, and a similar trend was found for TEWL, although it was not statistically significant.
Alcohol-based disinfectant caused less visible skin irritation and less skin barrier disruption than the use of detergent. The alternate use of detergent and disinfectant caused less irritation than the use of detergent, and a possible interaction between the two irritants was not indicated. After 4 weeks there was a tendency for decreased skin reactivity in the skin areas which had 4 weeks previously been exposed to disinfectant.
酒精基消毒剂用于正常皮肤的益处一直存在争议。
本研究的目的是比较连续10天反复接触酒精基消毒剂、洗涤剂以及酒精基消毒剂/洗涤剂交替使用的效果，评估中包括非侵入性测量。还评估了间隔4周后受刺激皮肤的皮肤反应性。
将洗涤剂、消毒剂以及交替使用的消毒剂和洗涤剂，每隔10分钟每天两次，每次1小时，涂抹于17名健康志愿者的上臂腹侧和前臂。设置一个对照区域。4周后，在每个区域贴上十二烷基硫酸钠贴片。在第1、5、11、38和40天，通过视觉评分记录对刺激性反应进行量化，并测量经表皮水分流失（TEWL）和皮肤颜色。
在第5天，洗涤剂引起的视觉评分高于单独使用的任何一种消毒剂或交替使用的消毒剂和洗涤剂，P<0.05。在第11天，洗涤剂和交替使用的消毒剂和洗涤剂引起的评分高于消毒剂，P<0.05。在第5天和第11天通过TEWL评估证实，与单独使用消毒剂以及交替使用消毒剂和洗涤剂相比，洗涤剂引起的刺激性反应增强，P<0.001，而通过颜色测量未发现显著差异。4周后，通过颜色测量评估发现，与对照区域和洗涤剂处理区域相比，消毒剂处理区域对十二烷基硫酸钠贴片的反应明显较小，经表皮水分流失也呈现类似趋势，尽管无统计学意义。
与使用洗涤剂相比，酒精基消毒剂引起的皮肤刺激和皮肤屏障破坏较小。洗涤剂和消毒剂交替使用引起的刺激比使用洗涤剂小，且未显示两种刺激物之间可能存在相互作用。4周后，4周前接触过消毒剂的皮肤区域有皮肤反应性降低的趋势。
