Bonatti Hugo, Hinder Ronald A, Klocker Josef, Neuhauser Beate, Klaus Alexander, Achem Sami R, de Vault Kenneth
Department of Surgery, Mayo Clinic Jacksonville, 4500 San Pablo Rd., Jacksonville, FL 32224, USA.
Am J Surg. 2005 Dec;190(6):874-8. doi: 10.1016/j.amjsurg.2005.08.012.
Treatment options for achalasia include medications, endoscopic balloon dilation, injection of botulinum toxin, or surgery.
The clinical course of 75 consecutive patients who underwent minimally invasive Heller myotomy and partial fundoplication for achalasia between 1991 and 2001 was reviewed by means of a questionnaire.
Mean follow-up was 5.3 (range .8 to 10.9) years. Sixty-four percent of questionnaires were returned. Thirty-seven patients (84%) felt much better and 6 (14%) slightly better; 1 (2%) rated the result as unchanged. Twenty-six patients (59%) experienced weight gain. Seven patients (16%) had persistent swallowing problems and 5 (11%) reported frequent reflux. Twenty-five percent underwent additional therapy, including dilation (n = 8, 18%), repeat surgery (n = 2, 5%), and botulinum toxin injection (n = 2, 5%). Eighteen patients (41%) were using a proton pump inhibitor or H2 blocker, three were on a calcium channel blocker (7%), and 1 was using nitroglycerine (2%).
Laparoscopic Heller myotomy can achieve short- and long-term results comparable to open surgery and should be considered the treatment of choice for patients suffering from achalasia. Despite the frequent need for further therapy, patient satisfaction is good.
贲门失弛缓症的治疗选择包括药物治疗、内镜下球囊扩张、肉毒杆菌毒素注射或手术。
通过问卷调查回顾了1991年至2001年间连续75例接受微创Heller肌切开术和部分胃底折叠术治疗贲门失弛缓症患者的临床病程。
平均随访时间为5.3年(范围0.8至10.9年)。64%的问卷得到回复。37例患者(84%)感觉好多了,6例(14%)感觉稍好一些;1例(2%)认为结果没有变化。26例患者(59%)体重增加。7例患者(16%)持续存在吞咽问题,5例(11%)报告频繁反流。25%的患者接受了额外治疗,包括扩张(8例,18%)、再次手术(2例,5%)和肉毒杆菌毒素注射(2例,5%)。18例患者(41%)正在使用质子泵抑制剂或H2阻滞剂,3例正在使用钙通道阻滞剂(7%),1例正在使用硝酸甘油(2%)。
腹腔镜Heller肌切开术可取得与开放手术相当的短期和长期效果,应被视为贲门失弛缓症患者的首选治疗方法。尽管经常需要进一步治疗,但患者满意度良好。