Matsuzaki Kazuhito, Uno Masaaki, Kageji Teruyoshi, Hirose Takanori, Nagahiro Shinji
Department of Neurosurgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.
Neurol Med Chir (Tokyo). 2005 Nov;45(11):591-5. doi: 10.2176/nmc.45.591.
A 64-year-old woman presented with a rare anaplastic ganglioglioma in the right cerebellopontine angle manifesting as dizziness persisting for 2 weeks. Preoperative magnetic resonance (MR) imaging revealed a partially enhanced cystic lesion of the right cerebellopontine angle. The tumor was subtotally removed through a right lateral suboccipital craniectomy. The tumor was thought to originate from the brain stem with exophytic growth into the right cerebellopontine angle. Histological examination showed neoplastic ganglional and glial cells with anaplastic features such as mitosis, pleomorphism, and endothelial proliferation. The MIB-1 labeling index of the glial components was 40% to 60%. The diagnosis was anaplastic ganglioglioma (World Health Organization grade IV). She received postoperative radiotherapy but died of respiratory failure with tumor recurrence 11 months after the operation. Gangliogliomas usually have a good prognosis. Histological features of anaplasia and a high MIB-1 labeling index may be predictive of a poor clinical outcome.
一名64岁女性因右小脑桥脑角罕见的间变性节细胞胶质瘤就诊，表现为持续2周的头晕。术前磁共振成像显示右小脑桥脑角有一个部分强化的囊性病变。通过右侧枕下外侧开颅手术将肿瘤次全切除。肿瘤被认为起源于脑干并向右侧小脑桥脑角外生性生长。组织学检查显示肿瘤性节细胞和胶质细胞具有间变特征，如有丝分裂、多形性和内皮细胞增殖。胶质成分的MIB-1标记指数为40%至60%。诊断为间变性节细胞胶质瘤（世界卫生组织IV级）。她接受了术后放疗，但术后11个月因肿瘤复发死于呼吸衰竭。节细胞胶质瘤通常预后良好。间变的组织学特征和高MIB-1标记指数可能预示临床结局不佳。
