谵妄相关的双硫仑与乙醇相互作用。
Delirium-associated disulfiram and ethanol interactions.
作者信息
Mirsal Hasan, Yalug Irem, Tan Devran, Stern Theodore A, Kalyoncu Ayhan, Pektas Ozkan, Erdogan Gamze, Beyazyürek Mansur
机构信息
Department of Psychiatry, Maltepe University, Istanbul, Turkey.
出版信息
Prim Care Companion J Clin Psychiatry. 2005;7(5):235-7. doi: 10.4088/pcc.v07n0505.
BACKGROUND
Disulfiram, an agent used for the treatment of alcohol dependence, can exacerbate psychiatric syndromes (including psychosis, catatonia, delirium, depression, and mania) after extended use. However, delirium has yet to be reported following the short-term use of disulfiram in the setting of alcohol use.
OBJECTIVES
We report a case with a neuropsychiatric presentation and discuss the prevention and the progression of delirium associated with an interaction of disulfiram and ethanol.
CASE REPORT
We report the case of a 51-year-old woman who developed disorganized speech, diminished communication, a decrease in appetite, and thoughts of suicide 10 days after she began taking disulfiram (250 mg/day), to which she added 1 glass of alcoholic beverage for 2 days. Delirium developed in association with an interaction between disulfiram and alcohol. The patient met DSM-IV criteria for major depressive disorder, alcohol dependence, and delirium.
DISCUSSION
Neuropsychiatric manifestations may develop in association with co-administration of disulfiram and alcohol; timely recognition and treatment are recommended.
背景
双硫仑是一种用于治疗酒精依赖的药物，长期使用后可加重精神综合征（包括精神病、紧张症、谵妄、抑郁和躁狂）。然而，在酒精使用的情况下，短期使用双硫仑后尚未有谵妄的报道。
目的
我们报告一例具有神经精神症状的病例，并讨论与双硫仑和乙醇相互作用相关的谵妄的预防和进展。
病例报告
我们报告一例51岁女性病例，该患者在开始服用双硫仑（250毫克/天）10天后出现言语紊乱、交流减少、食欲下降和自杀念头，在此期间她又饮用了2天的一杯酒精饮料。谵妄是由双硫仑和酒精的相互作用引起的。该患者符合《精神疾病诊断与统计手册》第四版中重度抑郁症、酒精依赖和谵妄的诊断标准。
讨论
双硫仑和酒精联合使用可能会出现神经精神表现；建议及时识别和治疗。
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