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重新审视青春期疾病发病率的性别差异。

Reconsidering the sex differences in the incidence of pubertal disorders.

作者信息

Papadimitriou A, Chrousos G P

机构信息

First Department of Pediatrics, Penteli Children's Hospital, Athens, Greece.

出版信息

Horm Metab Res. 2005 Nov;37(11):708-10. doi: 10.1055/s-2005-870586.

Abstract

The age range of normal puberty is determined statistically; therefore, a similar percentage of boys and girls should present early or late puberty. However, far more girls present with precocious puberty and more boys with delayed puberty. We suggest that the gender differences in the incidence of pubertal disorders may be due to the following: The signs of puberty are more readily detected in girls, whereas male genitalia may not be examined during a physical examination. The description of the onset of puberty in boys is not uniform. The secular trend towards earlier pubertal maturation is more intense in girls than in boys. Therefore, there may be a fall in the age that correspond to the 3rd and 97th centiles for onset of puberty in girls while the ages at these centiles remain practically unchanged in boys. The high ratio of males to females with constitutional delay of puberty may also be attributed to the late appearance of the pubertal growth spurt in boys. The sex differences in the incidence of pubertal disorders may be due to gender dimorphism in the secular changes of pubertal maturation, to the difficulty of detecting the onset of puberty in boys and to the physiological sex differences in the timing of the pubertal growth spurt.

摘要

正常青春期的年龄范围是通过统计学确定的;因此,出现青春期提前或延迟的男孩和女孩的比例应相近。然而,出现性早熟的女孩远比男孩多,而青春期延迟的男孩则更多。我们认为,青春期疾病发病率的性别差异可能归因于以下几点:青春期的体征在女孩中更容易被察觉,而在体格检查时可能不会检查男性生殖器。男孩青春期开始的描述并不统一。女孩青春期早熟的长期趋势比男孩更为明显。因此,对应女孩青春期开始的第3百分位数和第97百分位数的年龄可能会下降,而男孩在这些百分位数对应的年龄实际上保持不变。青春期体质性延迟的男性与女性比例较高,也可能归因于男孩青春期生长突增出现较晚。青春期疾病发病率的性别差异可能是由于青春期成熟的长期变化中的性别二态性、检测男孩青春期开始的困难以及青春期生长突增时间上的生理性性别差异。

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