Fajmut Ales, Jagodic Marko, Brumen Milan
Department of Physics, University of Maribor, Koroska cesta 160, SI-2000 Maribor, Slovenia.
J Chem Inf Model. 2005 Nov-Dec;45(6):1605-9. doi: 10.1021/ci050177i.
The mathematical model presented here describes the interactions among Ca2+, calmodulin (CaM), and myosin light chain kinase (MLCK) and consists of a kinetic scheme taking into account 7 reactions instead of 12 as proposed previously. We derive a system of 5 nonlinear ordinary differential equations. Solving it yields the prediction of active MLCK as a function of [Ca2+] whereby the active MLCK is defined to be proportional to the Ca4CaM.MLCK complex concentration. The model predictions are compared with other theoretical and experimental predictions of active MLCK as well as with the results of our previously proposed complex model.
本文提出的数学模型描述了钙离子（Ca2+）、钙调蛋白（CaM）和肌球蛋白轻链激酶（MLCK）之间的相互作用，该模型由一个动力学方案组成，此方案考虑了7个反应，而非先前提出的12个反应。我们推导出一个由5个非线性常微分方程组成的系统。求解该系统可得出活性MLCK作为[Ca2+]的函数的预测结果，其中活性MLCK被定义为与Ca4CaM.MLCK复合物浓度成正比。将该模型的预测结果与活性MLCK的其他理论和实验预测结果以及我们先前提出的复杂模型的结果进行了比较。
