肌动蛋白结构波动对肌球蛋白V步长的影响。

Influence of fluctuations in actin structure on myosin V step size.

作者信息

Vilfan Andrej

机构信息

J. Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia.

出版信息

J Chem Inf Model. 2005 Nov-Dec;45(6):1672-5. doi: 10.1021/ci050182m.

DOI:10.1021/ci050182m

PMID:16309271

Abstract

We study the influence of helical disorder in the actin structure on the myosin V step size, predicted from the elastic lever arm model. We show that fluctuations of +/-5 degrees per actin subunit, as proposed by Egelman et al., significantly alter the distribution of step sizes and improve the agreement with experimental data.

摘要

我们研究了肌动蛋白结构中的螺旋紊乱对肌球蛋白V步长的影响，这是根据弹性杠杆臂模型预测的。我们发现，如埃格尔曼等人所提出的，每个肌动蛋白亚基±5度的波动会显著改变步长分布，并改善与实验数据的吻合度。