从利血平合成去甲利血平。
Synthesis of deserpidine from reserpine.
作者信息
Varchi Greta, Battaglia Arturo, Samorì Cristian, Baldelli Eleonora, Danieli Bruno, Fontana Gabriele, Guerrini Andrea, Bombardelli Ezio
机构信息
Istituto CNR per la Sintesi Organica e Fotoreattività ISOF, Area della Ricerca di Bologna, Via P., Gobetti 101, 40129 Bologna, Italy.
出版信息
J Nat Prod. 2005 Nov;68(11):1629-31. doi: 10.1021/np050179x.
PMID:16309312
Abstract
The Rauwolfia alkaloids reserpine (1) and deserpidine (2), two alkaloids from Rauwolfia species, have been widely used for their antihypertensive action. Deserpidine (2) is a compound with limited availability from natural sources, and its synthesis from 1 in six steps (41% overall yield) is reported here.
摘要
萝芙木生物碱利血平（1）和去甲利血平（2）是从萝芙木属植物中提取的两种生物碱，因其降压作用而被广泛使用。去甲利血平（2）是一种天然来源有限的化合物，本文报道了由1经六步合成该化合物的方法（总收率41%）。
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