Sleipness Evan P, Sorg Barbara A, Jansen Heiko T
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, P.O. Box 646520, Pullman, 99164, USA.
Brain Res. 2005 Dec 14;1065(1-2):132-7. doi: 10.1016/j.brainres.2005.10.017. Epub 2005 Nov 23.
To test the hypothesis that time of day influences the locomotor effects of cocaine in rats, we measured short- and long-term sensitization to cocaine at five different Zeitgeber times (ZT). Short-term sensitization was expressed equally at all ZTs tested. Long-term sensitization was expressed only at dark onset, suggesting a possible influence of melatonin. Exogenous melatonin given immediately before cocaine challenge slightly enhanced long-term sensitization. Taken together, the present results support a time-of-day influence on locomotor sensitization to cocaine.
为了验证一天中的时间会影响可卡因对大鼠运动效应这一假设，我们在五个不同的授时因子时间（ZT）测量了对可卡因的短期和长期敏感化。在所有测试的ZT中，短期敏感化表现相同。长期敏感化仅在黑暗开始时出现，提示褪黑素可能有影响。在给予可卡因激发前立即给予外源性褪黑素会轻微增强长期敏感化。综上所述，目前的结果支持一天中的时间对可卡因运动敏感化有影响。
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