散发性嗜铬细胞瘤治疗期间家族性混合性高脂血症的脂质和脂蛋白代谢：一项病例研究。
Lipid and lipoprotein metabolism in familial combined hyperlipidaemia during treatment of sporadic phaeochromocytoma: a case study.
作者信息
Winocour P H, Masud T, Clark F, Cooper B G, Laker M F, Alberti K G
机构信息
University of Newcastle upon Tyne Department of Medicine, Medical School, UK.
出版信息
Postgrad Med J. 1992 May;68(799):371-5. doi: 10.1136/pgmj.68.799.371.
Lipid metabolism was evaluated during management of phaeochromocytoma in a 41 year old non-obese post-menopausal women with familial combined hyperlipidaemia. The main effect of the excess catecholamine secretion on lipid metabolism was increased lipolytic activity, lower serum triglyceride and increased HDL cholesterol concentrations, compared with findings following removal of the tumour. Before removal of the tumour, the use of beta blockers alone led to marked deterioration of the hyperlipidaemic state, and combined alpha and beta blockade additionally led to a marked reduction in fat oxidation and lipoprotein lipase activity. Overactivity of the adrenergic system leads to changes in lipid metabolism in phaeochromocytoma. Treatment of the phaeochromocytoma may lead to worsening of hyperlipidaemia pre-existing in such individuals.
对一名41岁、非肥胖、绝经后、患有家族性混合性高脂血症的嗜铬细胞瘤女性患者在治疗期间的脂质代谢情况进行了评估。与肿瘤切除后的结果相比，过量儿茶酚胺分泌对脂质代谢的主要影响是脂解活性增加、血清甘油三酯降低以及高密度脂蛋白胆固醇浓度升高。在肿瘤切除前，单独使用β受体阻滞剂会导致高脂血症状态明显恶化，而联合使用α和β受体阻滞剂还会导致脂肪氧化和脂蛋白脂肪酶活性显著降低。肾上腺素能系统的过度活跃会导致嗜铬细胞瘤患者脂质代谢发生变化。嗜铬细胞瘤的治疗可能会使这类个体原本存在的高脂血症恶化。
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