脱氢表雄酮（DHEA）可减轻大鼠自我给药模型中的觅可卡因行为。
Dehydroepiandrosterone (DHEA) attenuates cocaine-seeking behavior in the self-administration model in rats.
作者信息
Maayan Rachel, Lotan Sharon, Doron Ravid, Shabat-Simon Maytal, Gispan-Herman Iris, Weizman Abraham, Yadid Gal
机构信息
Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Beilinson Campus, Petah Tikva, Israel.
出版信息
Eur Neuropsychopharmacol. 2006 Jul;16(5):329-39. doi: 10.1016/j.euroneuro.2005.10.002. Epub 2005 Nov 23.
The aim of this study was to determine the possible involvement of the neurosteroid dehydroepiandrosterone (DHEA) in cocaine-seeking behavior in a self-administration model in rats. DHEA pretreatment (continued thereafter concomitantly with cocaine self-administration) attenuated cocaine-seeking behavior and elevated the levels of dopamine and serotonin in several brain regions relevant to cocaine addiction. Chronic cocaine self-administration induced elevation in brain DHEA, its sulfate ester, DHEAS, and pregnenolone. The increased brain DHEA following cocaine self-administration may serve as a compensatory protective mechanism geared to attenuate the craving for cocaine. Such anti-craving activity is further enhanced by DHEA treatment before and during cocaine self-administration.
本研究的目的是确定神经甾体脱氢表雄酮（DHEA）在大鼠自我给药模型中对可卡因觅求行为的潜在影响。DHEA预处理（此后在可卡因自我给药期间持续进行）减弱了可卡因觅求行为，并提高了与可卡因成瘾相关的几个脑区中的多巴胺和5-羟色胺水平。长期可卡因自我给药导致脑内DHEA、其硫酸酯（DHEAS）和孕烯醇酮水平升高。可卡因自我给药后脑内DHEA的增加可能是一种补偿性保护机制，旨在减轻对可卡因的渴望。在可卡因自我给药之前和期间进行DHEA治疗可进一步增强这种抗渴望活性。
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