School of Sports Medicine and Health, Chengdu Sport University, Chengdu, 610041, P. R. China.
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
BMC Psychiatry. 2023 Nov 17;23(1):852. doi: 10.1186/s12888-023-05351-1.
Methamphetamine (MA) abuse is recognized as a brain disorder, and physical activity has clear benefits for MA use disorders. The specific mechanisms by which physical activity alleviates MA use disorders are currently not fully understood. Based on this, the present study used untargeted metabolomics using liquid chromatography-mass spectrometry (LC-MS) to analyze the metabolic changes induced by MA in the brains of mice by exercise intervention. It was found that after 2 weeks of treadmill training, aerobic exercise modulated MA-induced brain metabolic disorders, in which 129 metabolites existed that were significantly differentiated in response to MA induction, and 32 metabolites were significantly affected by exercise. These differential metabolites were mainly enriched in glycerophospholipid metabolism, steroid hormone biosynthesis and degradation, and renin-angiotensin system pathways. To our knowledge, this study is the first to use LC-MS to investigate the effects of aerobic exercise on MA-induced brain metabolic profiling. The findings of this study provide new insights into exercise therapy using MA.
甲基苯丙胺（MA）滥用被认为是一种大脑障碍，而身体活动对 MA 使用障碍有明显的益处。目前，身体活动缓解 MA 使用障碍的具体机制尚不完全清楚。基于此，本研究采用液相色谱-质谱联用（LC-MS）的非靶向代谢组学方法，分析运动干预对 MA 诱导的小鼠大脑代谢紊乱的影响。结果发现，经过 2 周的跑步机训练，有氧运动调节了 MA 诱导的大脑代谢紊乱，其中有 129 种代谢物对 MA 的诱导有明显的差异，32 种代谢物受到运动的显著影响。这些差异代谢物主要富集在甘油磷脂代谢、甾体激素生物合成和降解以及肾素-血管紧张素系统途径中。据我们所知，这是首次使用 LC-MS 研究有氧运动对 MA 诱导的大脑代谢组学的影响。本研究的结果为 MA 使用的运动疗法提供了新的见解。
