Vallini A, Davi D, Candi L
Quad Sclavo Diagn. 1976 Sep;12(3):329-48.
The AA. have observed some patients suffering from persistent chronic hepatitis, aggressive chronic hepatitis, severe virus hepatitis, hepatic cirrhosis, hepatic metastasis, cholecystolithiasis, hepatic abscess, congestic heart disorder, alcoholism also patients treated with barbiturics and benzodiazepine, comparising in the meanwhile gamma-glutamyl-transaminase. They would suggest a new interpretation: the observed enzyme was higher in the obstructive diseases, gamma-GT also notable higher in the cellular hepatic diseases (hepatitis, cirrhosis and so on). In their opinion gamma-GT should be a regular enzymatic screening for liver diseases, but should not anyway eliminate the till now used enzymes.
作者们观察了一些患有持续性慢性肝炎、侵袭性慢性肝炎、重症病毒性肝炎、肝硬化、肝转移、胆结石、肝脓肿、充血性心脏病、酒精中毒的患者,以及同时接受巴比妥类和苯二氮䓬类药物治疗的患者,同时检测了γ-谷氨酰转肽酶。他们提出了一种新的解释:在阻塞性疾病中观察到的该酶水平较高,在肝细胞性疾病(肝炎、肝硬化等)中γ-GT也显著升高。他们认为γ-GT应该作为肝病的常规酶学筛查指标,但无论如何都不应摒弃目前使用的酶类指标。