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用于生物应用的双通道光纤表面等离子体共振传感研究。

Investigation of dual-channel fiber-optic surface plasmon resonance sensing for biological applications.

作者信息

Peng Wei, Banerji Soame, Kim Yoon-Chang, Booksh Karl S

机构信息

Arizona Applied NanoSensors, Department of Chemistry and Biochemistry, Arizona State University, Tempe 85287-1604, USA.

出版信息

Opt Lett. 2005 Nov 15;30(22):2988-90. doi: 10.1364/ol.30.002988.

DOI:10.1364/ol.30.002988
PMID:16315697
Abstract

A dual-channel fiber-optic sensor based on surface plasmon resonance (SPR) for self-referencing refractive-index measurements has been proposed. Most applications of fiber-optic SPR sensors are designed to measure the refractive index of a liquid or gas sample by measuring the signal from a single surface, the sensitivity and stability of which is easily affected by the fluctuation of external environmental conditions. We have designed a dual-channel fiber-optic surface sensor with two independent SPR signals from two areas of the same probe. A prototype sensor was fabricated and characterized. The preliminary experimental results demonstrate the characteristic responses of both SPR signals from two channels that independently correspond to the refractive index changes in the liquid samples with which they are in contact. The design could be extended to a multichannel sensor with further developments. The experimental results confirmed that one channel can be used as a reference sensor that could compensate for unexpected changes in bulk refraction or temperature and develop this sensor as a practicable high-sensitivity biosensing device.

摘要

提出了一种基于表面等离子体共振(SPR)的双通道光纤传感器,用于自参考折射率测量。光纤SPR传感器的大多数应用旨在通过测量来自单个表面的信号来测量液体或气体样品的折射率,其灵敏度和稳定性很容易受到外部环境条件波动的影响。我们设计了一种双通道光纤表面传感器,该传感器来自同一探头两个区域的两个独立SPR信号。制作并表征了一个原型传感器。初步实验结果表明,两个通道的SPR信号都具有特征响应,它们独立对应于与之接触的液体样品中的折射率变化。随着进一步发展,该设计可扩展为多通道传感器。实验结果证实,一个通道可以用作参考传感器,该参考传感器可以补偿整体折射或温度的意外变化,并将该传感器开发成为一种实用的高灵敏度生物传感装置。

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