Ford J J, Yoshinaga K
Endocrinology. 1975 Feb;96(2):335-9. doi: 10.1210/endo-96-2-335.
Treatment of pseudopregnant rats with ergocryptine mesylate (ECR) depressed serum prolactin levels but had no apparent effect on LH secretion. Ovarian progesterone secretion was significantly, reduced 24 hr after ECR treatment on day 6 or 9 of pseudopregnancy and the secretion rate of 20alpha-OH-P remained constant. When lactating rats nursing 6 pups were treated with ECR on day 6 or 9 postpartum, progesterone secretion was significantly decreased by 48 hr after treatment and 20 alpha-OH-P secretion was not altered. Furthermore, ECR inhibited litter weight gains of these lactating dams. After treatment of normal pregnant and pregnant lactating rats with ECR on day 6 of pregnancy, gestation was terminated in all animals. If ECR was given on day 9 to normal pregnant rats, to pregnant lactating animals whose pups were removed on day 9 postpartum, or to pregnant lactating rats treated with LH, gestation was not terminated. However, treatment with ECR of day 9 pregnant lactating rats whose pups continued to suckle terminated pregnancy in 13 of 21 animals. The results of these studies suggest the elevated pituitary prolactin secretion is necessary for maintenance of luteal function in pseudopregnant and lactating rats, and in pregnant lactating rats elevated pituitary prolactin secretion is a component of the luteotrophic complex for a longer period of time than in normal pregnant rats.
用甲磺酸麦角隐亭（ECR）处理假孕大鼠可降低血清催乳素水平，但对促黄体生成素（LH）分泌无明显影响。在假孕第6天或第9天用ECR处理24小时后，卵巢孕酮分泌显著减少，而20α-羟孕酮（20α-OH-P）的分泌率保持不变。在产后第6天或第9天用ECR处理哺乳6只幼崽的泌乳大鼠时，处理后48小时孕酮分泌显著减少，而20α-OH-P的分泌未改变。此外，ECR抑制了这些泌乳母鼠的窝仔体重增加。在妊娠第6天用ECR处理正常妊娠和妊娠泌乳大鼠后，所有动物的妊娠均终止。如果在第9天给正常妊娠大鼠、产后第9天幼崽被取出的妊娠泌乳动物或用LH处理的妊娠泌乳大鼠给予ECR，则妊娠不会终止。然而，对第9天幼崽继续吮乳的妊娠泌乳大鼠用ECR处理，21只动物中有13只妊娠终止。这些研究结果表明，垂体催乳素分泌升高对于维持假孕和泌乳大鼠的黄体功能是必要的，并且在妊娠泌乳大鼠中，垂体催乳素分泌升高作为黄体营养复合体的一个组成部分的时间比正常妊娠大鼠更长。
