α-肾上腺素能阻滞剂对大鼠心脏心室自律性的影响
Alpha-adrenergic blockers on ventricular automatism in rat heart.
作者信息
Tamargo J, Serrano J, García de Jalón P, de Andrés F
出版信息
Rev Esp Fisiol. 1977 Mar;33(1):63-6.
The role of the alpha-adrenergic receptors in the genesis of cardiac arrhythmias induced in the isolated rat right ventricle has been studied. The administration of six alpha-adrenergic blocking agents (phenoxybenzamine, dibenamine, phentolamine, tolazoline, azapetine and SY-28) did not alter the automatism induced. Even when can not be excluded the existance of alpha-adrenergic receptors in the rat ventricle, it is clear that alpha-blocking drugs are ineffective to abolish the arrhythmias induced by an increase in the activity of the Purkinje fibers.
α-肾上腺素能受体在离体大鼠右心室诱发心律失常中的作用已得到研究。给予六种α-肾上腺素能阻滞剂（酚苄明、双苄明、酚妥拉明、妥拉唑啉、阿扎哌汀和SY-28）并未改变所诱发的自律性。即使不能排除大鼠心室中存在α-肾上腺素能受体，但很明显，α-阻滞剂对消除由浦肯野纤维活性增加所诱发的心律失常无效。
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