Achim Amélie M, Lepage Martin
Brain Imaging Group, Douglas Hospital Research Centre-FBCI, 6875 Boulevard LaSalle, Verdun, Québec H4H 1R3, Canada.
Br J Psychiatry. 2005 Dec;187:500-9. doi: 10.1192/bjp.187.6.500.
Numerous studies have examined the neural correlates of episodic memory deficits in schizophrenia, yielding both consistencies and discrepancies in the reported patterns of results.
To identify in schizophrenia the brain regions in which activity is consistently abnormal across imaging studies of memory.
Data from 18 studies meeting the inclusion criteria were combined using a recently developed quantitative meta-analytic approach.
Regions of consistent differential activation between groups were observed in the left inferior prefrontal cortex, medial temporal cortex bilaterally, left cerebellum, and in other prefrontal and temporal lobe regions. Subsequent analyses explored memory encoding and retrieval separately and identified between-group differences in specific prefrontal and medial temporal lobe regions.
Beneath the apparent heterogeneity of published findings on schizophrenia and memory, a consistent and robust pattern of group differences is observed as a function of memory processes.
众多研究探讨了精神分裂症发作性记忆缺陷的神经关联，报告的结果模式既有一致性，也存在差异。
在精神分裂症患者中识别出在记忆成像研究中活动始终异常的脑区。
采用最近开发的定量荟萃分析方法，合并了18项符合纳入标准的研究数据。
在左侧前额叶下回、双侧内侧颞叶皮质、左侧小脑以及其他前额叶和颞叶区域观察到组间一致的差异激活区域。随后的分析分别探讨了记忆编码和提取，并确定了特定前额叶和内侧颞叶区域的组间差异。
在已发表的关于精神分裂症与记忆的研究结果表面异质性之下，观察到作为记忆过程函数的一致且稳健的组间差异模式。
