Fireman Zvi, Neiman Elena, Abu Mouch Saif, Kopelman Yael
Gastroenterology Department, Hillel Yaffe Medical Center, Hadera, Israel.
Digestion. 2005;72(4):223-7. doi: 10.1159/000089921. Epub 2005 Nov 23.
BACKGROUND/AIMS: To compare the current differences with our earlier findings on the incidence and locations of colorectal cancer (CRC) among Israeli-born Jews and Arabs living within the same central coastal region in Israel.
Data on demographics and the incidence and locations of malignancies were retrieved from hospital files of pathology-diagnosed patients with CRC throughout 1997-2003 and compared with equivalent data from 1988 to 1996.
Of the 624 patients recently diagnosed as having CRC, 562 (90.1%) were Jews and 62 (9.9%) were Arabs (p < 0.001). The average age of the entire cohort was significantly lower since our earlier study (72.9 +/- 12.5 compared to 67.9 +/- 12.7 years, p < 0.0001). The Jewish patients were significantly younger (p < 0.0001) but the Arab patients were not. The percentage of the adenocarcinoma being located in the right colon was significantly lower (p < 0.0006) and significantly higher in the rectum (p < 0.008). The reverse was true among the Jewish patients, but not significantly.
Both study groups were younger than those in our earlier study. The lower incidence of CRC among the Arab patients persisted over time, but the location of their adenocarcinoma changed significantly. The increased incidence of CRC in 'westernized' countries is reflected in the Jewish but not the Arab community.
背景/目的：比较以色列同一中部沿海地区出生的犹太人和阿拉伯人在结直肠癌（CRC）发病率和发病部位方面与我们早期研究结果的当前差异。
从1997年至2003年病理诊断为CRC患者的医院档案中检索人口统计学数据以及恶性肿瘤的发病率和发病部位数据，并与1988年至1996年的等效数据进行比较。
在最近诊断为患有CRC的624例患者中，562例（90.1%）为犹太人，62例（9.9%）为阿拉伯人（p<0.001）。整个队列的平均年龄比我们早期研究时显著降低（72.9±12.5岁，而之前为67.9±12.7岁，p<0.0001）。犹太患者明显更年轻（p<0.0001），但阿拉伯患者并非如此。腺癌位于右半结肠的比例显著降低（p<0.0006），而位于直肠的比例显著升高（p<0.008）。犹太患者情况相反，但差异不显著。
两个研究组都比我们早期研究中的组更年轻。阿拉伯患者中CRC发病率较低的情况长期存在，但他们腺癌的发病部位发生了显著变化。“西方化”国家CRC发病率的上升在犹太人群体中有所体现，但在阿拉伯人群体中没有。
