激素、羽化与果蝇：蜕皮激素对变态发育的分子调控
Hormones, puffs and flies: the molecular control of metamorphosis by ecdysone.
作者信息
Andres A J, Thummel C S
机构信息
Howard Hughes Medical Institute, Eccles Institute of Human Genetics, University of Utah, Salt Lake City 84112.
出版信息
Trends Genet. 1992 Apr;8(4):132-8. doi: 10.1016/0168-9525(92)90371-A.
PMID:1631956
Abstract
Pulses of the steroid hormone ecdysone during late larval and prepupal development in Drosophila coordinate the activation of a large number of primary and secondary response genes, signalling the onset of metamorphosis. Molecular characterization of some of these genes has provided valuable clues to regulatory mechanisms by which the ecdysone signal is transduced and amplified.
摘要
在果蝇幼虫后期和蛹前期发育过程中，类固醇激素蜕皮激素的脉冲协调了大量初级和次级反应基因的激活，标志着变态的开始。对其中一些基因的分子特征分析为蜕皮激素信号转导和放大的调控机制提供了有价值的线索。
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