铁色锡马木（苦木科）根茎的植物化学性质和抗溃疡特性
Phytochemical and antiulcerogenic properties of rhizomes from Simaba ferruginea St. Hill. (Simaroubaceae).
作者信息
Noldin Vânia Floriani, de Oliveira Martins Domingos Tabajara, Marcello César Marcos, da Silva Lima Joaquim Corsino, Delle Monache Franco, Cechinel Filho Valdir
机构信息
Programa de Mestrado em Ciências Farmacêuticas e Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí, Santa Catarina, Brazil.
出版信息
Z Naturforsch C J Biosci. 2005 Sep-Oct;60(9-10):701-6. doi: 10.1515/znc-2005-9-1007.
Simaba ferruginea (Simaroubaceae) is a Brazilian medicinal plant used in traditional medicine to treat several ailments, including gastric ulcers, fever, diarrhea, and dolorous and inflammatory processes. This study examines the chemical composition and antiulcerogenic effects of rhizomes from this plant. Bioassay-guided fractionation led to the isolation of two bioactive indole alkaloids called canthin-6-one (1) and 4-methoxycanthin-6-one (2). The alkaloid fraction and both alkaloids demonstrated potent antiulcerogenic effects when evaluated in gastric lesion-induced animals, as well as significant antinociceptive activity in mice. These results confirm and justify the popular use of S. ferruginea against gastric ulcers and dolorous processes.
锈毛洋椿（苦木科）是一种巴西药用植物，在传统医学中用于治疗多种疾病，包括胃溃疡、发烧、腹泻以及疼痛和炎症过程。本研究考察了该植物根茎的化学成分和抗溃疡作用。通过生物活性导向分离，得到了两种具有生物活性的吲哚生物碱，即6-酮基-咔啉（1）和4-甲氧基-6-酮基-咔啉（2）。在致胃溃疡动物模型中评估时，生物碱部位和这两种生物碱均表现出强效抗溃疡作用，并且在小鼠中具有显著的镇痛活性。这些结果证实并说明了锈毛洋椿在治疗胃溃疡和疼痛过程中的广泛应用是合理的。
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