Bhatti Sajid Nazir, Ayub Shahid, Aurangzeb Ahsan, Haq Anwar Ul, Jamil M, Ali Johar, Ahmad Ayesha, Kashif M
Department of Neurosurgery, Ayub Medical College & Teaching Hospital, Abbottabad.
J Ayub Med Coll Abbottabad. 2005 Jul-Sep;17(3):26-8.
Deep seated lesions of the brain cannot be approached by conventional neurosurgical approach stereotactic system offers minimally invasive and accurate approach to such lesions. This study was carried out with an objective to determine the safety, efficacy and diagnostic yield of stereotactic biopsies of brain lesions using Brown-Roberts-Wells (BRW) system.
This study was carried out in patients with intracranial lesions at Ayub teaching hospital Abbottabad from September 1999 to October 2003. Suitable patients with intra cranial lesions underwent computerized stereo tactic biopsy with BRW system. Tissue specimens were analyzed in histopathology department of the Ayub Medical College and results were obtained. Data was analyzed via computer software SPSS 8.0 version for windows.
Fifteen patients were selected for stereotactic brain biopsy. Age ranged from 15 years to 54 years. Among them 09 (60%) were male and 06 (40%) were female patients. Out come of the procedure was highly promising in terms of safety and positive diagnostic yield in 14 patients (93.3%), and histopathalogical validity of results (93.3%). Only one patient suffered mild neurological deficit (6.7%), one patient had inconclusive tissue diagnosis and invalid result (6.7%). biopsy proven lesion was astrocytoma in 04 patients (26.7%), anaplastic astrocytoma in 04 (26.7%), gliomatosis in 02 (13.3%), tuberculomas in 03 (20.0%). metastatic adenocarcinomas in 01 (6.7%) and lymphoma in 01(6.7%).
We conclude that computerized stereotactic brain biopsy is safe and effective procedure with a high diagnostic yield at our center.
传统神经外科手术方法无法触及脑深部病变，立体定向系统为此类病变提供了微创且精确的手术途径。本研究旨在确定使用布朗 - 罗伯茨 - 韦尔斯（BRW）系统对脑病变进行立体定向活检的安全性、有效性及诊断率。
本研究于1999年9月至2003年10月在阿伯塔巴德阿尤布教学医院对颅内病变患者开展。合适的颅内病变患者接受了使用BRW系统的计算机立体定向活检。组织标本在阿尤布医学院病理科进行分析并得出结果。数据通过适用于Windows的计算机软件SPSS 8.0版本进行分析。
15例患者接受了立体定向脑活检。年龄范围为15岁至54岁。其中9例（60%）为男性，6例（40%）为女性患者。就安全性而言，该手术的结果很有前景，14例患者（93.3%）获得了阳性诊断率，且结果具有组织病理学有效性（93.3%）。仅1例患者出现轻度神经功能缺损（6.7%），1例患者组织诊断不明确且结果无效（6.7%）。活检证实的病变中，4例（26.7%）为星形细胞瘤，4例（26.7%）为间变性星形细胞瘤，2例（13.3%）为胶质瘤病，3例（20.0%）为结核瘤，1例（6.7%）为转移性腺癌，1例（6.7%）为淋巴瘤。
我们得出结论，在我们中心，计算机立体定向脑活检是一种安全有效的手术，诊断率很高。
