Vermel' A E
Klin Med (Mosk). 2005;83(10):51-7.
A range of prospective studies have proven high efficacy of omega3-polyunsaturated fatty acids (omega3-FA, cod-liver oil (CLO)) in secondary prophylaxis of atherosclerosis and its complications. Monotherapy with CLO or its combination with statines in natients with hypertriglyceridemia substantially lowers triglyceride level. Due to their anti-inflammatory properties, including the capability of prostaglandin production reduction, clinical application of omega3-FA is indicated in high risk of preterm delivery, and in patients with rheumatoid arthritis. In the latter CLO application allows reduction of the dose of nonsteroidal anti-inflammatory drugs, and improves chief clinical symptoms (reduces pain and morning joint stiffness.)
一系列前瞻性研究已证明ω-3多不饱和脂肪酸（ω-3-FA，鱼肝油（CLO））在动脉粥样硬化及其并发症的二级预防中具有高效性。在高甘油三酯血症患者中，单用CLO或其与他汀类药物联合使用可大幅降低甘油三酯水平。由于其具有抗炎特性，包括降低前列腺素生成的能力，ω-3-FA的临床应用适用于早产高危人群以及类风湿性关节炎患者。对于后者，应用CLO可减少非甾体抗炎药的剂量，并改善主要临床症状（减轻疼痛和晨僵）。
