局部应用芝麻油对大鼠氧化应激的影响。
Effects of topical sesame oil on oxidative stress in rats.
作者信息
Chiang James Po-Jung, Hsu Dur-Zong, Tsai Jui-Chen, Sheu Hamm-Ming, Liu Ming-Yie
机构信息
Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan.
出版信息
Altern Ther Health Med. 2005 Nov-Dec;11(6):40-5.
OBJECTIVE
To assess the effects of topical sesame oil on systemic oxidative stress in rats.
DESIGN
Oxidative stress was induced with lipopolysaccharide and assessed by determining serum lipid peroxidation, superoxide anion, and hydroxyl radical levels. The levels of 3 circulating antioxidants--superoxide dismutase, catalase, and glutathione--also were determined.
RESULTS
Topical sesame oil significantly reduced lipid peroxidation, superoxide anion, and hydroxyl radical levels after lipopolysaccharide administration. However, sesame oil did not affect the 3 circulating antioxidants. Further, sesame oil decreased the activity of xanthine oxidase and nitric oxide production in lipopolysaccharide-treated rats.
CONCLUSION
Sesame oil given topically might attenuate oxidative stress by inhibiting the production of xanthine oxidase and nitric oxide in rats.
目的
评估局部应用芝麻油对大鼠全身氧化应激的影响。
设计
用脂多糖诱导氧化应激，并通过测定血清脂质过氧化、超氧阴离子和羟自由基水平进行评估。还测定了3种循环抗氧化剂——超氧化物歧化酶、过氧化氢酶和谷胱甘肽的水平。
结果
局部应用芝麻油显著降低了脂多糖给药后的脂质过氧化、超氧阴离子和羟自由基水平。然而，芝麻油并未影响这3种循环抗氧化剂。此外，芝麻油降低了脂多糖处理大鼠的黄嘌呤氧化酶活性和一氧化氮生成。
结论
局部应用芝麻油可能通过抑制大鼠黄嘌呤氧化酶和一氧化氮的生成来减轻氧化应激。
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