Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.
Shock. 2010 Jan;33(1):88-92. doi: 10.1097/SHK.0b013e3181a98de4.
Gentamicin, an aminoglycoside antibiotic, is widely used in the treatment of Gram-negative infections; however, dose-limiting nephrotoxicity restricts its optimal use. We investigated the effect of a daily sesame oil supplement on oxidative-stress-associated renal injury induced by a single daily dose of gentamicin in rats. Renal injury was induced by a single subcutaneous daily dose of gentamicin (100 mg kg(-1) d(-1) for 7 days), and then the effects of oral sesame oil (0.25, 0.5, and 1 mL kg(-1) d(-1) for 7 days) on renal injury, oxidative stress, hydroxyl radical, superoxide anion, and NO were assessed after treatment. Sesame oil inhibited gentamicin-induced renal injury, lipid peroxidation, hydroxyl radical, and superoxide anion, as well as NO production. In addition, sesame oil inhibited xanthine oxidase activity and inducible NOS expression in gentamicin-challenged rats. We hypothesize that a daily sesame oil supplement attenuates oxidative-stress-associated renal injury by reducing oxygen free radicals and lipid peroxidation in gentamicin-treated rats.
庆大霉素，一种氨基糖苷类抗生素，被广泛用于治疗革兰氏阴性感染；然而，剂量限制的肾毒性限制了其最佳使用。我们研究了每天补充芝麻油对单次给予庆大霉素诱导的大鼠氧化应激相关肾损伤的影响。通过单次皮下给予庆大霉素（100mg/kg/d，持续 7 天）诱导肾损伤，然后评估口服芝麻油（0.25、0.5 和 1ml/kg/d，持续 7 天）对治疗后肾损伤、氧化应激、羟自由基、超氧阴离子和 NO 的影响。芝麻油抑制了庆大霉素诱导的肾损伤、脂质过氧化、羟自由基和超氧阴离子以及 NO 的产生。此外，芝麻油抑制了庆大霉素处理大鼠黄嘌呤氧化酶活性和诱导型 NOS 表达。我们假设，每天补充芝麻油通过减少氧自由基和脂质过氧化来减轻庆大霉素引起的氧化应激相关肾损伤。
