一种用于制备针对半胱氨酸蛋白酶的多种氮杂肽探针的通用固相方法。

A general solid phase method for the preparation of diverse azapeptide probes directed against cysteine proteases.

作者信息

Kato Daisuke, Verhelst Steven H L, Sexton Kelly B, Bogyo Matthew

机构信息

Department of Pathology, Stanford School of Medicine, Stanford, California 94305, USA.

出版信息

Org Lett. 2005 Dec 8;7(25):5649-52. doi: 10.1021/ol052275v.

DOI:10.1021/ol052275v

PMID:16321013

Abstract

[chemical reaction: see text]. A solid phase approach is presented for the synthesis of azapeptide inhibitors and activity based probes (ABPs) for cysteine proteases. This synthetic method allows the incorporation of diverse reactive warheads linked to different peptide recognition elements. Application of this method to the synthesis of a series of caspase probes is described.

摘要

[化学反应：见正文]。本文介绍了一种用于合成氮杂肽抑制剂和基于活性的半胱氨酸蛋白酶探针（ABP）的固相方法。这种合成方法允许引入与不同肽识别元件相连的多种反应性弹头。描述了该方法在一系列半胱天冬酶探针合成中的应用。