来自赞比亚豆蔻种子的五种半日花烷二萜类化合物。

Five labdane diterpenoids from the seeds of Aframomum zambesiacum.

作者信息

Kenmogne Marguerite, Prost Elise, Harakat Dominique, Jacquier Marie-José, Frédérich Michel, Sondengam Lucas B, Zèches Monique, Waffo-Téguo Pierre

机构信息

Department of Chemistry, Faculty of Science, University of Dschang, Box 67, Dschang, Cameroon.

出版信息

Phytochemistry. 2006 Mar;67(5):433-8. doi: 10.1016/j.phytochem.2005.10.015.

DOI:10.1016/j.phytochem.2005.10.015

PMID:16321410

Abstract

Five labdane diterpenoids, (3-5), zambesiacolactone A (7) and zambesiacolactone B (8), were isolated from the seeds of Aframomum zambesiacum (Baker) K. Schum., along with five known labdanes and a linear sesquiterpene, nerolidol. Their structures were elucidated by spectroscopic analysis. Their antiplasmodial activity was evaluated in vitro against Plasmodium falciparum. Compound 3 was the most active with an IC(50) value of 4.97 microM.

摘要

从赞比亚豆蔻（Aframomum zambesiacum (Baker) K. Schum.）的种子中分离出了5种半日花烷二萜（3 - 5）、赞比亚内酯A（7）和赞比亚内酯B（8），以及5种已知的半日花烷和一种直链倍半萜——橙花叔醇。通过光谱分析阐明了它们的结构。体外评估了它们对恶性疟原虫的抗疟活性。化合物3活性最强，IC50值为4.97微摩尔。