Subramani Ramesh, Narayanasamy Mathivanan, Feussner Klaus-D
Department of Biology, School of Sciences, College of Engineering, Science and Technology, Fiji National University, Natabua Campus, Lautoka, Fiji.
Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, India.
3 Biotech. 2017 Jul;7(3):172. doi: 10.1007/s13205-017-0848-9. Epub 2017 Jun 29.
Antibiotic resistance is becoming a pivotal concern for public health that has accelerated the search for new antimicrobial molecules from nature. Numbers of human pathogens have inevitably evolved to become resistant to various currently available drugs causing considerable mortality and morbidity worldwide. It is apparent that novel antibiotics are urgently warranted to combat these life-threatening pathogens. In recent years, there have been an increasing number of studies to discover new bioactive compounds from plant origin with the hope to control antibiotic-resistant bacteria. This review attempts to focus and record the plant-derived compounds and plant extracts against multi-drug-resistant (MDR) pathogens including methicillin-resistant Staphylococcus aureus (MRSA), MDR-Mycobacterium tuberculosis and malarial parasites Plasmodium spp. reported between 2005 and 2015. During this period, a total of 110 purified compounds and 60 plant extracts were obtained from 112 different plants. The plants reviewed in this study belong to 70 different families reported from 36 countries around the world. The present review also discusses the drug resistance in bacteria and emphasizes the urge for new drugs.
抗生素耐药性正成为公共卫生领域的一个关键问题，这加速了从自然界寻找新型抗菌分子的进程。许多人类病原体不可避免地进化出了对各种现有药物的耐药性，在全球范围内导致了相当高的死亡率和发病率。显然，迫切需要新型抗生素来对抗这些危及生命的病原体。近年来，越来越多的研究致力于从植物中发现新的生物活性化合物，以期控制耐药细菌。本综述旨在聚焦并记录2005年至2015年间报道的针对多重耐药（MDR）病原体的植物源化合物和植物提取物，这些病原体包括耐甲氧西林金黄色葡萄球菌（MRSA）、多重耐药结核分枝杆菌以及疟原虫属疟原虫。在此期间，共从112种不同植物中获得了110种纯化化合物和60种植物提取物。本研究中所综述的植物属于来自世界36个国家报道的70个不同科。本综述还讨论了细菌中的耐药性，并强调了对新药的迫切需求。
