具有互穿聚合物网络结构的pH响应性两亲水凝胶网络：一种控制药物释放的策略。

pH-responsive amphiphilic hydrogel networks with IPN structure: a strategy for controlled drug release.

作者信息

Liu Yu-Yang, Fan Xiao-Dong, Wei Bo-Rong, Si Qing-Fa, Chen Wei-Xing, Sun Le

机构信息

Department of Applied Chemistry, School of Science, Northwestern Polytechnic University, Xi'an 710072, PR China.

出版信息

Int J Pharm. 2006 Feb 3;308(1-2):205-9. doi: 10.1016/j.ijpharm.2005.10.013.

DOI:10.1016/j.ijpharm.2005.10.013

PMID:16321489

Abstract

A pH-responsive amphiphilic hydrogel with interpenetrating polymer networks (IPN) structure for controlled drug release was proposed. The IPN was constructed with hydrophilic poly(acrylic acid) (PAA) and hydrophobic poly(butyl acrylate) (PBA). Using drug N-acetyl-5-methoxytryptamine (melatonin, MEL) as a model molecule, the controlled drug release behaviors of the IPN were investigated. It is found that not only the release of MEL from the IPN can respond to change in pH, but also the presence of hydrophobic network can overcome disadvantageous burst effect of hydrophilic network. This may be a result of hydrophobic aggregation encapsulating MEL molecules.

摘要

提出了一种具有互穿聚合物网络（IPN）结构的pH响应性两亲水凝胶用于药物控释。该IPN由亲水性聚丙烯酸（PAA）和疏水性聚丙烯酸丁酯（PBA）构建而成。以药物N-乙酰-5-甲氧基色胺（褪黑素，MEL）作为模型分子，研究了IPN的药物控释行为。结果发现，MEL从IPN中的释放不仅能响应pH值的变化，而且疏水网络的存在可以克服亲水网络不利的突释效应。这可能是疏水聚集体包裹MEL分子的结果。