Suárez Carmen, Villar José, Martel Nieves, Extremera Blas Gil, Suliman Najaty, Campo Carlos, Castellanos Victoriano, Liébana Antonio, Rodilla Enrique, Nieto Javier, Velasco Olga, Ruilope Luis M
Servicio de Medicina Interna, Hospital Universitario de la Princesa Madrid, Diego de León 62, 28006 Madrid, Spain.
Int J Cardiol. 2006 Jan 4;106(1):41-6. doi: 10.1016/j.ijcard.2004.12.076.
Left ventricular hypertrophy is an important predictor of cardiovascular risk and its detection contributes to risk stratification. However, echocardiography is not a routine procedure and electrocardiography (ECG) underestimates its prevalence.
To evaluate the prevalence of echocardiographic left ventricular hypertrophy in low and medium risk non-treated hypertensive subjects, in order to find out the percentage of them who would be reclassified as high risk patients.
Cross-sectional, multicenter study was performed in hospital located hypertension units. An echocardiogram was performed in 197 previously untreated hypertensive patients, > 18 years, classified as having low (61%) or medium (39%) risk, according to the OMS/ISH classification. The presence of left ventricular hypertrophy was considered if left ventricular mass index was > or = 134 or 110 g/m(2) in men and women, respectively (Devereux criteria). A logistic regression analysis was performed to identify factors associated to left ventricular hypertrophy.
The prevalence of left ventricular hypertrophy was 23.9% (95% CI:17.9-29.9), 25.6% in men and 22.6% in women. In the low risk group its prevalence was 20.7% and in medium risk group 29.5%. Factors associated to left ventricular hypertrophy were: years since the diagnosis of hypertension, OR:1.1 (95% CI:1.003-1.227); systolic blood pressure, OR:1.08 (95% CI:1.029-1.138); diastolic blood pressure, OR:0.9 (95% CI:0.882-0.991); and family history of cardiovascular disease, OR:4.3 (95% CI:1.52-12.18).
These findings underline the importance of performing an echocardiogram in low and high risk untreated hypertensive patients in which treatment would otherwise be delayed for even one year.
左心室肥厚是心血管疾病风险的重要预测指标,其检测有助于风险分层。然而,超声心动图并非常规检查项目,而心电图(ECG)会低估其患病率。
评估中低风险未治疗高血压患者超声心动图左心室肥厚的患病率,以确定其中会被重新分类为高风险患者的比例。
在医院高血压科室进行横断面多中心研究。对197例年龄大于18岁、根据世界卫生组织/国际高血压学会(OMS/ISH)分类被归类为低风险(61%)或中风险(39%)的未治疗高血压患者进行了超声心动图检查。如果男性左心室质量指数≥134 g/m²,女性≥110 g/m²(德弗罗标准),则认为存在左心室肥厚。进行逻辑回归分析以确定与左心室肥厚相关的因素。
左心室肥厚的患病率为23.9%(95%置信区间:17.9 - 29.9),男性为25.6%,女性为22.6%。低风险组患病率为20.7%,中风险组为29.5%。与左心室肥厚相关的因素有:高血压诊断后的年限,比值比(OR):1.1(95%置信区间:1.003 - 1.227);收缩压,OR:1.08(95%置信区间:1.029 - 1.138);舒张压,OR:0.9(95%置信区间:0.882 - 0.991);以及心血管疾病家族史,OR:4.3(95%置信区间:1.52 - 12.18)。
这些发现强调了对中低风险未治疗高血压患者进行超声心动图检查的重要性,否则治疗可能会延迟甚至一年。