The First Geriatric Cardiology Department, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Chin Med J (Engl). 2012 Jan;125(1):21-6.
Left ventricular hypertrophy (LVH) and geometric abnormality are associated with morbidity and mortality of cardiovascular disease and stroke. Hypertension is the major cause of LVH. Yet the prevalence and other risk factors of LVH and geometric abnormality in Chinese hypertensive population are unknown. The objective of this study was to investigate the prevalence and risk factors of LVH and geometric abnormality in community-based Chinese hypertensive population.
The study was a community-based cross-sectional study, and comprised 4270 hypertension patients with integrated clinical and echocardiographic data. Left ventricular mass was measured by transthoracic echocardiography. LVH was diagnosed by using the criteria of over 49.2 g/m(2.7) for men and 46.7 g/m(2.7) for women. LV geometric patterns (normal, concentric remodeling, concentric or eccentric hypertrophy) were calculated according to LVH and relative wall thickness. Logistic regression model was used to determine the odds ratio (OR) and 95% confidence intervals (CI) of the risk factors of LVH.
The prevalence of LVH was 42.7% in 4270 hypertensive patients, with 37.4% in males and 45.4% in females, respectively. The prevalence of concentric remodeling, concentric or eccentric hypertrophy was 24.7%, 20.2%, and 22.6%, respectively. In Logistic regression model, female (OR 1.3, 95%CI 1.1 - 1.5, P < 0.01), age (OR 1.02, 95%CI 1.01 - 1.03, P < 0.01), body mass index (OR 1.2, 95%CI 1.15 - 1.20, P < 0.01), systolic blood pressure (OR 1.02, 95%CI 1.01 - 1.03, P < 0.01), and serum triglyceride (OR 1.10, 95% CI 1.00 - 1.20, P < 0.01) were risk factors of LVH. Female, age, body mass index, systolic blood pressure and serum triglyceride were also risk factors of left ventricular geometric abnormality.
The echocardiographic LVH is the major complication of patients with hypertension in rural area of China, especially for women. To effectively treat hypertension, weight loss and control of serum triglyceride may help to prevent LVH in hypertensive population.
左心室肥厚（LVH）和几何异常与心血管疾病和中风的发病率和死亡率有关。高血压是 LVH 的主要原因。然而，中国高血压人群中 LVH 和几何异常的患病率和其他危险因素尚不清楚。本研究的目的是调查社区内中国高血压人群中 LVH 和几何异常的患病率和危险因素。
本研究为社区为基础的横断面研究，纳入了 4270 例具有综合临床和超声心动图数据的高血压患者。左心室质量通过经胸超声心动图测量。LVH 采用男性超过 49.2 g/m2.7 和女性超过 46.7 g/m2.7 的标准进行诊断。根据 LVH 和相对壁厚度计算 LV 几何模式（正常、同心重构、同心或偏心肥厚）。使用 logistic 回归模型确定 LVH 危险因素的比值比（OR）和 95%置信区间（CI）。
4270 例高血压患者中 LVH 的患病率为 42.7%，男性为 37.4%，女性为 45.4%。同心重构、同心或偏心肥厚的患病率分别为 24.7%、20.2%和 22.6%。在 logistic 回归模型中，女性（OR 1.3，95%CI 1.1-1.5，P < 0.01）、年龄（OR 1.02，95%CI 1.01-1.03，P < 0.01）、体重指数（OR 1.2，95%CI 1.15-1.20，P < 0.01）、收缩压（OR 1.02，95%CI 1.01-1.03，P < 0.01）和血清甘油三酯（OR 1.10，95%CI 1.00-1.20，P < 0.01）是 LVH 的危险因素。女性、年龄、体重指数、收缩压和血清甘油三酯也是左心室几何异常的危险因素。
超声心动图 LVH 是中国农村地区高血压患者的主要并发症，尤其是女性。为了有效治疗高血压，减轻体重和控制血清甘油三酯可能有助于预防高血压人群中的 LVH。
