Tytor M, Olofsson J
Department of Otolaryngology, Linköping University Hospital, Sweden.
Acta Otolaryngol Suppl. 1992;492:75-8. doi: 10.3109/00016489209136815.
This retrospective study of 176 patients with oral cavity carcinoma showed that nearly 60% of the patients presented with an advanced stage of disease. The duration of symptoms was shorter in patients with a large tumour than with a small (p less than 0.001) and in patients with metastases than in those without (p less than 0.01). Lymph node metastases were more common in large tumours (p less than 0.01), in tumours with high malignancy grading (p less than 0.05) and in non-diploid tumours (p less than 0.001). The presence of lymph node metastases (p less than 0.001), tumour size (p less than 0.01) and tumour DNA ploidy (p less than 0.005) were the only parameters that significantly influenced survival (Cox regression analysis).
这项对176例口腔癌患者的回顾性研究表明，近60%的患者疾病处于晚期。大肿瘤患者的症状持续时间比小肿瘤患者短（p<0.001），有转移的患者比无转移的患者短（p<0.01）。淋巴结转移在大肿瘤（p<0.01）、高恶性分级肿瘤（p<0.05）和非二倍体肿瘤中更常见（p<0.001）。淋巴结转移的存在（p<0.001）、肿瘤大小（p<0.01）和肿瘤DNA倍体（p<0.005）是显著影响生存的唯一参数（Cox回归分析）。
