Mest H J, Rein T, Riedel A, Köpernik W, Braquet C
Department of Pharmacology and Toxicology, Martin Luther University, Halle, Germany.
Agents Actions Suppl. 1992;37:228-34. doi: 10.1007/978-3-0348-7262-1_32.
The threshold dose of ouabain necessary to induce ventricular fibrillation is decreased in sensitized guinea-pigs signalizing an enhanced arrhythmogenicity. Esculetine or WEB 2170 antagonists of histamine and PAF, respectively and especially a combination of both can increase the threshold dose of ouabain-induced fibrillation demonstrating an antiarrhythmic effect. BN 52256 a substance with multi-antagonistic properties shows antiarrhythmic effect in this method, too. WEB 2170 and BN 52256 decrease the incidence of ventricular fibrillation after coronary ligation in rats.
在致敏豚鼠中，诱发心室颤动所需的哇巴因阈值剂量降低，这表明致心律失常性增强。七叶亭或分别为组胺和血小板活化因子拮抗剂的WEB 2170，尤其是两者的组合，可增加哇巴因诱发颤动的阈值剂量，显示出抗心律失常作用。具有多种拮抗特性的物质BN 52256在该方法中也显示出抗心律失常作用。WEB 2170和BN 52256可降低大鼠冠状动脉结扎后心室颤动的发生率。
