Safety and efficacy of cytoreductive surgery for epithelial ovarian cancer in elderly and high-risk surgical patients.
作者信息
Sharma Sameer, Driscoll Deborah, Odunsi Kunle, Venkatadri Arun, Lele Shashikant
机构信息
Division of Gynecologic Oncology, Department of Surgery, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
出版信息
Am J Obstet Gynecol. 2005 Dec;193(6):2077-82. doi: 10.1016/j.ajog.2005.06.074.
OBJECTIVE
Surgery is the cornerstone of management in ovarian cancer. However, in high-risk and elderly patients there is a tendency for less aggressive surgery upfront. The aim of this study was to review cytoreductive surgery, with focus on complications and outcomes in patients with multiple surgical risk factors.
STUDY DESIGN
Charts of patients with ovarian cancer from 1998 to 2002 were retrospectively reviewed.
RESULTS
One hundred and forty patients were treated for ovarian cancer. Sixty-three patients (45%) were elderly (> or =65 years), and 69 patients (49%) had comorbidities. Optimal debulking (< or =1 cm) was achieved in 123 patients (88%). There was no significant relation between complications and type of procedure, elderly age, comorbidities, or transfusions. Optimally debulked patients had a significantly longer survival than patients with suboptimal debulking (P < .001).
CONCLUSION
Aggressive optimal cytoreduction can be achieved in the majority of patients with multiple surgical risk factors and is associated with a low complication rate.
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