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Expression of pS2 gene in human breast cancer cell line MCF-7 is controlled by retinoic acid.

作者信息

Hirota M, Furukawa Y, Hayashi K

机构信息

Department of Molecular Biology, Gifu Parmaceutical University, Japan.

出版信息

Biochem Int. 1992 May;26(6):1073-8.

PMID:1632803
Abstract

We established a simplified method for the quantitative measurement of pS2 mRNA using the reverse transcriptase-polymerase chain reaction (RT-PCR) method. Expression of the pS2 gene, which is transcriptionally induced by estrogen in breast cancer cell line MCF-7 cells, can be repressed by retinoic acid (RA) in unstimulated cells. The suppressive effect of RA on pS2 mRNA was inhibited by cycloheximide.

摘要

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