Rusińska Agnieszka, Chlebna-Sokół Danuta
Department of Paediatric Propedeutics and Bone Metabolic Diseases, Medical University of Łódź 36/50 Sporna St., 91-738 Łódź, Poland.
Clin Chim Acta. 2006 Apr;366(1-2):257-63. doi: 10.1016/j.cca.2005.10.014. Epub 2005 Dec 5.
The aim of the study was to determine whether the serum concentration of insulin-like growth factor-I (IGF-I) and its binding protein-3 (IGFBP-3) correlates with the mineral metabolism markers in children with idiopathic decrease in bone mass.
The study comprised 62 patients aged 6-18 years, including 42 with idiopathic decrease in bone mineral density (20 with osteoporosis and 22 with osteopenia) and 20 control children. Osteoporosis and osteopenia were diagnosed on the basis of complex clinical, densitometric and biochemical examinations (in all patients secondary causes of the decreased bone mass were excluded). Serum concentration of IGF-I was determined with radioimmunoassay and IGFBP-3 using immunoradiometry.
The children with osteoporosis and osteopenia were found to have mean IGF-I concentration statistically significantly lower than the controls (548 and 645 v. 819 ng/ml, respectively; p<0.05). Moreover, IGF-I correlated positively with total and spinal bone mineral density. In children with osteoporosis there was also a significant relationship between IGF-I and pyridinoline and deoxypyridinoline in urine.
Lower serum IGF-I concentration together with higher bone resorption and low bone mineral density reveal involvement of this growth factor in the development of idiopathic decrease of bone mass in children.
本研究旨在确定胰岛素样生长因子-I（IGF-I）及其结合蛋白-3（IGFBP-3）的血清浓度是否与特发性骨量减少儿童的矿物质代谢标志物相关。
本研究纳入62例6至18岁的患者，其中包括42例特发性骨密度降低患者（20例骨质疏松症患者和22例骨质减少症患者）以及20例对照儿童。骨质疏松症和骨质减少症是基于综合临床、骨密度测量和生化检查诊断的（所有患者均排除了骨量减少的继发原因）。采用放射免疫分析法测定血清IGF-I浓度，采用免疫放射分析法测定IGFBP-3浓度。
发现骨质疏松症和骨质减少症患儿的平均IGF-I浓度在统计学上显著低于对照组（分别为548和645 vs. 819 ng/ml；p<0.05）。此外，IGF-I与总骨密度和脊柱骨密度呈正相关。在骨质疏松症患儿中，IGF-I与尿中吡啶啉和脱氧吡啶啉之间也存在显著关系。
较低的血清IGF-I浓度、较高的骨吸收和较低的骨密度表明该生长因子参与了儿童特发性骨量减少的发生发展。
