Blanco Eduardo, Picón Isabel M, Miranda Ruben, Begega Azucena, Conejo Nélida M, Arias Jorge L
Laboratorio de Psicobiología, Facultad de Psicología, Universidad de Oviedo, Plaza Feijoo, s/n, CP 33003 Oviedo, Spain.
Neurosci Lett. 2006 Feb 27;395(1):82-6. doi: 10.1016/j.neulet.2005.10.061. Epub 2005 Dec 5.
The sexual differences in cerebral nuclei are produced by the organizational and the activational function of gonadal hormones. The different performances by male and female rats in memory tasks requiring use of the mammillary bodies (MBs), could be due to structural and functional sexual dimorphic differences. Our work quantifies the number of glial fibrillary acidic protein immunoreactive (GFAP-IR) astrocytes, and neuronal metabolic activity measured by the cytochrome oxidase (CO) histochemistry in the MBs in rats of both sexes. We find that there is no difference in astroglial number in the medial mammillary nucleus (MMN) and in the lateral mammillary nucleus (LMN) of males, females in estrus and diestrus adult rats. However, we do find statistically significant differences between the sexes in the neuronal oxidative metabolism influenced by the estrous cycle. We, therefore, conclude that there are functional and not structural sex differences in the MBs.
脑内核团的性别差异是由性腺激素的组织和激活作用产生的。雄性和雌性大鼠在需要使用乳头体（MBs）的记忆任务中的不同表现，可能归因于结构和功能上的性别二态性差异。我们的研究对两性大鼠乳头体中胶质纤维酸性蛋白免疫反应性（GFAP-IR）星形胶质细胞的数量进行了量化，并通过细胞色素氧化酶（CO）组织化学测量了神经元的代谢活性。我们发现，成年雄性大鼠、处于发情期和动情间期的雌性大鼠的内侧乳头核（MMN）和外侧乳头核（LMN）中的星形胶质细胞数量没有差异。然而，我们确实发现，受发情周期影响的神经元氧化代谢在两性之间存在统计学上的显著差异。因此，我们得出结论，乳头体中存在功能而非结构上的性别差异。
