Taboada M C, Rodriguez B, Millán R, Míguez I
Department of Physiology, Faculty of Pharmacy, University of Santiago de Compostela, Spain.
Biomed Pharmacother. 2006 Jan;60(1):10-3. doi: 10.1016/j.biopha.2005.07.014. Epub 2005 Oct 27.
We investigated whether dietary supplementation with L-arginine, the endogenous precursor of nitric oxide, might affect serum parameter levels body weight, food intake and activities of intestinal mucosa enzymes in animals fed with a standard diet or a diet high in saturated fat for 4 weeks. Body weight and food intake were not affected by diet but relative liver weight was higher in animals receiving a high-fat diet. Total cholesterol, LDL-cholesterol and triglyceride levels were higher in both groups fed high-fat diet and dietary L-arginine did not affect these parameters but produced an increase in serum protein levels and a slight decrease in glycaemia. Regarding the intestinal enzyme activities, rats fed a high-fat diet plus arginine showed the lowest intestinal disaccharidase activities.
我们研究了膳食补充一氧化氮的内源性前体L-精氨酸是否会影响以标准饮食或富含饱和脂肪的饮食喂养4周的动物的血清参数水平、体重、食物摄入量和肠黏膜酶活性。体重和食物摄入量不受饮食影响，但接受高脂饮食的动物相对肝脏重量较高。高脂饮食喂养的两组动物的总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平均较高，膳食L-精氨酸不影响这些参数，但会使血清蛋白水平升高，血糖略有降低。关于肠道酶活性，喂食高脂饮食加精氨酸的大鼠肠双糖酶活性最低。
