Cai Hua-bo
Department of Emergency, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310016, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2005 Nov;34(6):562-5. doi: 10.3785/j.issn.1008-9292.2005.06.018.
To determine the serum levels of CD62p (alpha-granular membrane protein) and CD63 (lysosome intact membrane protein) in patients with head injury and to observe its relation to injury severity.
Fifty-three patients with head injury were divided into 3 groups; Group A patients with mild head injury; Group B with moderate head injury; and Group C with severe head injury. The serum levels of CD62p, CD63 were measured on 12 h, d 1, 3, 5 and 7 after injury.
The serum levels of CD62p and CD63 in Group B and Group C were higher than those in Group A and control (P<0.05). The serum level of CD62p in Group C was higher than that in Group B (P<0.05). The serum levels of CD62p in Group C on d 1, 3, 5 after injury were higher than those on 12 h (P<0.05). The serum level of CD63 in Group B on d 3 after injury were higher than that on 12 h (P<0.05). The serum levels of CD63 in Group C on d 1, 3, 5 after injury were higher than those on 12 h (P<0.05).
The serum levels of CD62p and CD63 in patients with head injury may be helpful for identifying the severity of injury, and CD62p seems to be more sensitive.
测定颅脑损伤患者血清中CD62p（α-颗粒膜蛋白）和CD63（溶酶体完整膜蛋白）水平，并观察其与损伤严重程度的关系。
将53例颅脑损伤患者分为3组；A组为轻度颅脑损伤患者；B组为中度颅脑损伤患者；C组为重度颅脑损伤患者。于伤后12小时、第1、3、5和7天测定血清CD62p、CD63水平。
B组和C组血清CD62p和CD63水平高于A组及对照组（P<0.05）。C组血清CD62p水平高于B组（P<0.05）。C组伤后第1、3、5天血清CD62p水平高于伤后12小时（P<0.05）。B组伤后第3天血清CD63水平高于伤后12小时（P<0.05）。C组伤后第1、3、5天血清CD63水平高于伤后12小时（P<0.05）。
颅脑损伤患者血清CD62p和CD63水平可能有助于判断损伤严重程度，且CD62p似乎更敏感。
