Corkey Britton K, Toste F Dean
Department of Chemistry, University of California, Berkeley, California 94720, USA.
J Am Chem Soc. 2005 Dec 14;127(49):17168-9. doi: 10.1021/ja055059q.
An enantioselective intramolecular Conia-ene reaction of beta-dicarbonyl compounds and alkynes to afford methylene cyclopentanes is described. The reaction employs a DTBMSegphos-Pd(II)/Yb(III) dual catalyst system that allows for the asymmetric synthesis of all-carbon quaternary centers and generates a product containing an alkene that can be further manipulated.
描述了一种β-二羰基化合物与炔烃的对映选择性分子内Conia-烯反应，以生成亚甲基环戊烷。该反应采用了DTBMSegphos-Pd(II)/Yb(III)双催化剂体系，可实现全碳季碳中心的不对称合成，并生成一种含有可进一步转化的烯烃的产物。
